Protein-binding assays in biological liquids using microscale thermophoresis

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Protein-binding assays in biological liquids using microscale thermophoresis.

Protein interactions inside the human body are expected to differ from the situation in vitro. This is crucial when investigating protein functions or developing new drugs. In this study, we present a sample-efficient, free-solution method, termed microscale thermophoresis, that is capable of analysing interactions of proteins or small molecules in biological liquids such as blood serum or cell...

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ژورنال

عنوان ژورنال: Nature Communications

سال: 2010

ISSN: 2041-1723

DOI: 10.1038/ncomms1093